Check out this article from the LA Times that picks through how awesome Red Dead Redemption is for its creators Take Two.
Take Two hadn't produced any hits beyond the Grand Theft Auto series. It's been fighting to stay in the black since the last GTA game debuted in 2008.
As of June 7, 2010, Red Dead Redemption has sold over 5 million units. Coolest part? Red Dead Redemption is also one of the only successful "original" games in years. Like the movie industry, top earners have mostly come from pre-existing brands like Modern Warfare (which ironically before it became its own brand, borrowed from the clout of Tom Clancy), brands like LEGO and Star Wars, and obviously, back to Take Two's only other success, the greatly serialized GTA.